The Biggest Mistakes People Make Starting Keto | Dominic D’Agostino, Ph.D.

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Peter Attia MD Dec 10, 2025

Audio Brief

Show transcript
This episode features Dom D'Agostino discussing common ketogenic diet mistakes and an optimal framework for weight loss. There are three key takeaways. First, tracking food and ketones is essential. Second, calories still count for weight loss. Third, prioritize high protein and fiber on a ketogenic diet. The biggest mistake is not tracking intake; consistently monitor calories, macronutrients, and blood ketones. Calories are crucial, as fat's density makes overeating easy. A 10 to 20 percent caloric deficit is the primary driver of fat loss. For weight loss, prioritize high protein, moderate fat, and high fiber from low-sugar vegetables. Overall, the discussion provides a practical guide for effective ketogenic dieting and weight loss.

Episode Overview

  • Dom D'Agostino outlines the most common mistakes people make when attempting to enter nutritional ketosis, with the primary error being a lack of tracking.
  • The discussion emphasizes that calories are a critical factor for weight loss, even on a ketogenic diet, debunking the myth that one can eat unlimited amounts of fat and protein.
  • A distinction is made between a "clinical" ketogenic diet, viewed as a metabolic therapy, and a more general approach for weight loss.
  • D'Agostino provides a framework for a successful weight-loss-oriented ketogenic diet, focusing on high protein, moderate fat, and high fiber from specific vegetable sources.

Key Concepts

  • Tracking is Essential: The biggest mistake people make on a ketogenic diet is not tracking food intake. It's crucial to track total calories, macronutrient ratios, and blood ketone levels to understand how diet affects physiology and to ensure a caloric deficit.
  • Calories Still Matter: The idea that calories don't count on a ketogenic diet is a myth. Due to the high caloric density of fat, it's easy to overeat and prevent weight loss. Creating a 10-20% energy deficit is the primary driver of fat loss.
  • Optimal Keto Formulation for Weight Loss: For the purpose of weight loss, the ideal ketogenic diet is high in protein, moderate in fat, and high in fiber. Carbohydrates should primarily come from fibrous vegetables.
  • Fibrous vs. Starchy Carbs: Not all vegetables are equal on a ketogenic diet. It's important to choose high-fiber, low-sugar vegetables (like broccoli, cauliflower, leafy greens) and be cautious of higher-sugar options (like cooked carrots, bell peppers, and tomatoes).

Quotes

  • At 00:09 - "Yeah, not tracking. I mean, people do it, they're just like, 'Oh, I'm just going to eat, you know, this or that,' and not track." - Dom D'Agostino explains that the most common mistake people make is failing to monitor their food intake.
  • At 01:43 - "I view a ketogenic diet as a prescription metabolic therapy." - Dom D'Agostino clarifies his perspective, distinguishing the diet's clinical application from its more casual use for weight loss.
  • At 04:36 - "Simple caloric restriction or creating even like a 10 or 20% energy deficit will be the big lever that's going to cure 90% of what most people are seeking the ketogenic diet for." - Dom D'Agostino highlights that achieving a modest calorie deficit is the most critical factor for successful weight loss, regardless of the diet type.

Takeaways

  • Track Your Intake and Ketones: If you are starting a ketogenic diet, use a tracking app to monitor your daily calories and macronutrients. Simultaneously measure your blood ketone levels to learn how your body responds to different foods and ensure you are achieving your goals.
  • Focus on High Protein and Fiber: To optimize a ketogenic diet for weight loss and satiety, prioritize high protein intake and ensure your limited carbohydrates come from high-fiber vegetables like leafy greens and broccoli.
  • Beware of Hidden Calories in Fat: Be mindful that fats and oils are extremely calorie-dense. Even small portions of nuts, cheese, or added oils can significantly increase your calorie total, so measure portions carefully to avoid accidentally overeating.