Are You at Risk? The Lp(a) Test Everyone Needs | The Proof Shorts EP #320

Episode Overview

• The speaker defines Lipoprotein(a) [Lp(a)] as a specific, genetically-determined subtype of LDL cholesterol that carries an extra protein.
• He outlines the various ways high Lp(a) increases cardiovascular risk, including promoting inflammation, blood clots, and plaque formation.
• The video explains that since Lp(a) levels are primarily genetic and stable, it should be tested at least once in a person's lifetime.
• Different units for measuring Lp(a) are discussed, highlighting the preferred method and what constitutes a low-risk level for each.

Key Concepts

• Lipoprotein(a) [Lp(a)] is a unique type of low-density lipoprotein with an additional protein that gives it distinct, harmful properties.
• Unlike other cholesterol markers, Lp(a) levels are almost entirely determined by genetics and do not fluctuate significantly with diet or lifestyle changes.
• Elevated Lp(a) is a significant risk factor for atherosclerosis (plaque in arteries), making the plaque more vulnerable, and can also contribute to aortic valve dysfunction.
• The two primary ways to measure Lp(a) are by mass (mg/dL) and by particle concentration (nmol/L), with the latter being the preferred method for assessing risk.

Quotes

• At 00:10 - "It is prothrombotic, pro-coagulant, it can be pro-inflammatory, pro-atherogenic, pro-osteogenic, and all of these things can lead to a heightened risk of atherosclerosis." - The speaker lists the multiple ways elevated Lp(a) can harm cardiovascular health.
• At 00:40 - "...people should do it at least once in a lifetime. It's primarily almost entirely driven by genetics." - Explaining why Lp(a) is a crucial one-time test rather than a recurring one.

Takeaways

• Consider getting your Lp(a) level tested at least once to understand your genetic risk for cardiovascular disease.
• Because Lp(a) is genetically determined, there is no need for repeated testing as levels remain stable throughout life.
• Elevated Lp(a) increases the risk of plaque buildup, makes that plaque more unstable, and promotes inflammation and blood clotting.
• When reviewing your lab results, aim for a particle concentration below 50 nmol/L or, if measured by mass, a level under 30 mg/dL.